Ubiquitin signatures on aggregating proteins in neurodegeneration - PubMed
6 hours ago
- #ubiquitin
- #protein-aggregation
- #neurodegeneration
- Ubiquitin modifications play a key role in the fate of aggregation-prone proteins in neurodegenerative diseases.
- Neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and ALS involve misfolded protein accumulation leading to neuronal loss.
- Ubiquitin signatures (linkage types, chain architectures, site specificities) regulate protein clearance, aggregation, or cellular propagation.
- Dysregulation of E3 ligases and deubiquitinases contributes to inefficient protein disposal and disease progression.
- Therapeutic strategies targeting ubiquitin pathways aim to degrade aggregating proteins for treating neurodegenerative diseases.