GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection - PubMed
7 days ago
- #GLP-1
- #coronary microcirculation
- #cardioprotection
- GLP-1 activates KATP channels in coronary pericytes to mediate cardioprotection via brain-gut-heart signaling.
- Coronary 'no-reflow' affects up to 50% of patients post-ischemia, leading to worse outcomes like reduced ejection fraction and increased infarct size.
- GLP-1 release from the gut, triggered by skeletal muscle ischemia, dilates coronary capillaries by activating pericyte KATP channels.
- Blocking or genetically deleting pericyte KATP channels abolishes the protective coronary capillary dilation.
- The study suggests pharmacological therapies targeting this pathway could improve post-infarct recovery by reducing no-reflow.