Design of a neutralizing and protective pan-encephalitic alphavirus receptor decoy protein - PubMed
6 hours ago
- #antiviral therapy
- #alphavirus
- #receptor decoy
- Researchers developed a pan-encephalitic alphavirus receptor decoy protein neutralizing VEEV, EEEV, and WEEV.
- The decoy combines domains from LDLRAD3 and VLDLR receptors and neutralizes viruses by binding to their entry sites.
- A bispecific scaffold with a PCDH10 domain extended protection to contemporary WEEV strains.
- The engineered decoy protected mice from infection, offering a potential therapeutic countermeasure.
- This design platform may be adaptable for developing treatments against viruses from other families.