Design, Synthesis, and Bioevaluation of Adamantane-1-Carboxamide N-Acylthioureas for Airway Antiallergic Therapy - PubMed
11 hours ago
- #antiallergic
- #PP4
- #asthma
- Study focuses on adamantane-1-carboxamide N-acylthioureas for airway antiallergic therapy.
- Airway epithelial cells (AECs) are the first defense against pollutants, linked to allergic asthma exacerbation.
- Compounds were synthesized and characterized using NMR, HR-ESI-MS, FT-IR, and UV-vis spectroscopy.
- Compound AD3 crystallized in the triclinic P-1 space group.
- AD4 upregulated protein phosphatase 4 (PP4) in BEAS-2B cells concentration-dependently.
- AD4 restored epithelial barrier integrity and reduced thymic stromal lymphopoietin (TSLP) production induced by diesel exhaust particles (DEP).
- First report identifying AD4 as a potential therapeutic for allergic asthma.