Towards causal validation and clinical translation of the PAK2-fibroblast axis in idiopathic pulmonary fibrosis - PubMed
5 hours ago
- #PAK2
- #fibroblast
- #idiopathic pulmonary fibrosis
- PAK2 marks fibrotic fibroblast niches in idiopathic pulmonary fibrosis (IPF).
- Causal validation, multicellular contextualisation, and lung-targeted delivery are needed before clinical translation.
- Spatial omics should guide both discovery and therapeutic decision-making.
- Authors declare no conflicts of interest.
- Comment on a related study identifying PAK kinase as a therapeutic target in IPF fibroblastic foci and dense fibrosis.