Vitamin E alleviates experimental autoimmune prostatitis by inhibiting the EGFR/MAPK pathway to reduce M1 macrophage polarization - PubMed
17 hours ago
- #EGFR/MAPK Pathway
- #Autoimmune Prostatitis
- #Vitamin E
- Vitamin E reduces symptoms in a mouse model of experimental autoimmune prostatitis (EAP) and lowers pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α.
- Mechanistically, Vitamin E inhibits macrophage M1 polarization by blocking the EGFR/MAPK pathway, with direct binding to EGFR confirmed via molecular docking and SPR.
- The study suggests Vitamin E as a potential treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by targeting inflammation through EGFR/MAPK suppression.