Expression of CD25 in Human Lung Mast Cells and its Regulation by IL-33 - PubMed
6 hours ago
- #IL-33
- #CD25
- #Lung Mast Cells
- CD25 expression on human mast cells is mainly linked to clonal mast cell disorders, but its regulation in normal tissue-resident mast cells is not well understood.
- IL-33, a key immune modulator, was found to induce CD25 and CD132 expression in human lung mast cells (HLMCs) without upregulating CD122, leading to enhanced IL-2 binding but no IL-2-mediated signaling.
- Single-cell RNA sequencing identified IL2RA+ mast cells as a distinct subpopulation with enriched IL-33 response signatures and upregulated immune signaling and inflammatory pathway genes.
- CD25+ HLMCs were detected in human lung tissues, showing heterogeneity in expression levels and spatial distribution.
- The study concludes that IL-33 upregulates CD25 expression in HLMCs, which is dynamically regulated in human lung tissues.