Replaying germinal center evolution on a quantified affinity landscape - PubMed
4 hours ago
- #germinal center
- #affinity maturation
- #evolutionary dynamics
- Experimental evolution model replays monoclonal germinal center reactions to study immunoglobulin gene evolution.
- Deep mutational scanning assigns affinities to B cells, revealing noisy but persistent selection on constrained affinity landscapes.
- Inferred fitness landscape recapitulates affinity maturation, suggesting features like permissiveness and plateauing are survivorship biases.
- Study clarifies evolutionary dynamics in germinal centers, beyond known cellular competition mechanics.
- Research involves disclosures, including patents and industry ties related to viral deep mutational scanning.