Human LFA-1 governs T cell immune surveillance of the skin - PubMed
5 hours ago
- #papillomavirus
- #LFA-1
- #immune surveillance
- Human LFA-1 (lymphocyte function-associated antigen 1) deficiency is linked to skin lesions caused by commensal papillomaviruses in otherwise healthy adults.
- LFA-1 deficiency results from inherited αL (CD11a) deficiency, distinct from inherited β2 (CD18) deficiency seen in children with invasive infections.
- Leukocyte development and function remain largely intact without LFA-1, except for impaired transendothelial migration of skin-tropic CLA+ memory T cells.
- Alternative integrins facilitate the extravasation of other leukocytes, including non-skin-tropic T cell subsets, to different tissues.
- LFA-1 is crucial for steady-state T cell homing to the skin and controlling papillomaviruses but is otherwise largely redundant in immune function.
- Integrin-mediated T cell compartmentalization is essential for organ-selective immune surveillance.