Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice - PubMed
7 hours ago
- #LRRK2
- #chromatin accessibility
- #Parkinson's disease
- Inflammatory signaling affects chromatin accessibility and gene expression of LRRK2 differently in humans and mice.
- Animal work was approved by the NIA Animal Care and Use Committee, following PHS Policy guidelines.
- Human samples were obtained from drug-resistant epilepsy patients undergoing surgical resection, with consent under NIH protocol 11-N-0051.
- The study highlights differences in LRRK2 regulation between species, relevant to Parkinson's disease research.
- Authors declare no competing interests.