Cholesterol-driven mitochondrial rejuvenation by quercetin nanotherapeutics restores implant osseointegration in diabetes - PubMed
4 hours ago
- #nanotherapeutics
- #diabetes
- #mitochondria
- Diabetes impairs implant osseointegration due to mitochondrial dysfunction in BMSCs.
- Qe@TNS nanotherapeutics deliver quercetin to restore mitochondrial function.
- Hyperglycemia disrupts cholesterol metabolism, affecting lipid rafts and mitochondrial quality control.
- Qe@TNS reverses lipid raft dysfunction, restoring cholesterol influx and antioxidant activity.
- Hyperglycemia increases mitochondrial succinate, triggering inflammation via the succinate/HIF-1α/IL-1β axis.
- Qe@TNS inhibits pro-inflammatory signaling while boosting anti-inflammatory IL-10.
- The therapy rejuvenates mitochondria, enhances osteogenesis, and improves implant integration in diabetes.