Foamy microglia link oxylipins to disease progression in multiple sclerosis - PubMed
4 hours ago
- #microglia
- #lipid metabolism
- #multiple sclerosis
- Identified foamy GPNMB+ microglia/macrophages linked to lesion expansion in secondary progressive multiple sclerosis.
- Lesions with foamy cells show disrupted lipid metabolism, lysosomal stress, and enhanced phagocytosis without pro-inflammatory signs.
- Enriched in oxylipins, bismonoacylglycerolphosphates, cholesterol esters, and increased B cell/IgG1 infiltration.
- Monoacylglycerol lipase (MAGL) emerged as a therapeutic target; inhibition promoted lesion recovery in a mouse model.
- Oxylipins in cerebrospinal fluid correlate with foamy lesions, suggesting biomarkers for disease progression.