Infection, vaccination and risk of dementia: a proposed immunological model - PubMed
7 hours ago
- #immunology
- #vaccination
- #dementia
- The prevalence of dementia, particularly Alzheimer's disease (AD), is increasing with ageing populations.
- AD pathology is linked to plaques and neurofibrillary tangles in the central nervous system.
- Risk of dementia correlates with infectious agents like human herpes viruses, flaviviruses, and SARS-CoV-2.
- Some vaccinations, such as BCG and AS01-adjuvanted vaccines, are associated with reduced dementia risk.
- Trained innate immunity may explain the non-specific protective effects of certain vaccines against dementia.
- An immunological model is proposed to connect vaccine mechanisms with dementia risk reduction.