Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study - PubMed
5 days ago
- #USP8 genotype
- #tumor recurrence
- #Cushing's disease
- Recurrence after successful pituitary surgery is a challenge in managing Cushing's disease, with no reliable predictors.
- Somatic USP8 variants are found in one-third of cases, but their association with recurrence was unclear.
- This international, retrospective study analyzed 435 patients (83% female) from 1989 to 2024.
- USP8 variants were detected in 45% of cases, and recurrence occurred in 18% of patients in immediate remission.
- Recurrence risk depended on USP8 status and tumor size, with higher rates for USP8-variant tumors (36.8%) vs. wildtype microadenomas (15.0%).
- Wildtype macroadenomas had the highest recurrence rate (44.5%).
- Combined USP8 genotype-tumor size stratification identified high-risk patients, improving personalized follow-up.
- Funding came from Deutsche Forschungsgemeinschaft, National Natural Science Funds of China, and CAMS Innovation Fund.