Multi-omics and machine learning reveal DPPC as a key contributor to colorectal cancer progression and tumor immune microenvironment remodeling - PubMed
5 hours ago
- #Tumor microenvironment
- #Multi-omics
- #Machine learning
- DPPC identified as causally linked to CRC risk via phosphatidylcholine metabolites.
- DPPC promotes tumor progression by inhibiting TNFSF14 secretion in the tumor microenvironment.
- Machine learning model using DPPC predicted CRC progression with ARL8A, MTUS1, and TMEM184A as key features validated by spatial transcriptomics.