Decoding Keloids: Single-Cell Heterogeneity, Emerging Role of Adipocytes, Molecular Biomarkers, and Therapeutic Implications in Skin of Color - PubMed
12 hours ago
- #keloids
- #fibrosis
- #skin of color
- Keloids are a chronic, fibroproliferative disorder triggered by wounds, characterized by excessive fibroblast activity and extracellular matrix deposition.
- Risk factors for keloids include genetic loci and are more prevalent in skin of color, though pathogenesis is not fully understood.
- Multiomic technologies have identified key cell populations and signaling networks involved in keloid formation.
- Adipocyte lipolysis, microRNA epigenetic regulation, and disrupted vitamin D signaling play roles in tissue repair and fibrosis.
- Genetic studies suggest heritable risk factors contribute to keloid development.
- Integration of multiomic and genetic approaches provides insights and potential therapeutic targets for keloids.