A cytomegalovirus-encoded lncRNA blocks cell-cycle progression - PubMed
5 hours ago
- #lncRNA
- #Cell-cycle arrest
- #Cytomegalovirus
- The viral long non-coding RNA RNA2.7 is the most abundant polyadenylated transcript during HCMV infection.
- RNA2.7 stabilizes host mRNAs by sequestering RNA-binding proteins, reshaping the cellular transcriptome.
- RNA2.7 is essential for HCMV-induced cell-cycle arrest at the G1-S transition when infection occurs in G1.
- RNA2.7 expression alone is sufficient to block cell-cycle progression, enhancing viral replication.
- An extended polyadenosine stretch within RNA2.7 is required for its cell-cycle blocking activity.