The interplay between mitophagy and ferroptosis in Alzheimer's disease: Mechanisms and therapeutic implications - PubMed
6 hours ago
- #Alzheimer's disease
- #mitophagy
- #ferroptosis
- Alzheimer's disease (AD) is characterized by amyloid-β plaques and neurofibrillary tangles.
- Mitophagy (clearance of damaged mitochondria) and ferroptosis (iron-dependent cell death) are key processes in AD neurodegeneration.
- Impaired mitophagy disrupts redox and iron homeostasis, increasing susceptibility to ferroptosis.
- Ferroptosis events, like lipid peroxidation, worsen mitochondrial dysfunction, creating a self-amplifying cycle.
- Potential therapeutic strategies include Urolithin A and ferroptosis inhibitors.
- Targeting the mitophagy-ferroptosis loop may offer a new therapeutic approach for AD.