LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia - PubMed
5 hours ago
- #VCID
- #Oxidized LDL
- #Cerebrovascular aging
- Vascular cognitive impairment and dementia (VCID) is a leading cause of cognitive decline in aging populations.
- VCID is driven by endothelial dysfunction, chronic inflammation, oxidative stress, and metabolic dysregulation.
- Aging worsens cerebrovascular damage by impairing endothelial function, compromising the blood-brain barrier (BBB), and promoting neuroinflammation.
- Oxidized LDL (oxLDL) disrupts endothelial homeostasis, enhances leukocyte adhesion, and triggers chronic inflammatory signaling.
- oxLDL-mediated oxidative stress exacerbates mitochondrial dysfunction and epigenetic alterations in cerebrovascular cells.
- These mechanisms contribute to neurovascular uncoupling, cerebral hypoperfusion, and cognitive decline.
- The review discusses therapeutic strategies targeting LDL oxidation, inflammation, and endothelial dysfunction to mitigate VCID.