Tubulin transforms Tau and α-synuclein condensates from pathological to physiological - PubMed
6 hours ago
- #protein condensation
- #microtubules
- #neurodegeneration
- Tubulin transforms Tau and α-synuclein (αSyn) condensates from pathological to physiological states.
- Tau and αSyn form heterotypic condensates linked to both physiological and pathological processes.
- Tubulin inhibits pathological oligomerization of Tau and αSyn while promoting microtubule polymerization.
- In the absence of Tubulin, Tau-driven condensation accelerates pathogenic Tau:αSyn heterodimer and amyloid fibril formation.
- Microtubule loss in neurons leads to pathological oligomer formation and neurite degeneration, whereas Tau condensation stabilizes microtubules.