Fibronectin 1 mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells - PubMed
6 hours ago
- #Mechanical Pressure
- #Fibronectin 1
- #Colorectal Cancer
- Fibronectin 1 expression is elevated in colorectal cancer patients and associated with distant metastasis.
- High fibronectin 1 levels serve as a poor prognostic factor for overall survival in colorectal cancer.
- Pressure enhances viability, proliferation, migration, and invasion in colorectal cancer cells and cancer stem cells through fibronectin 1.
- Combined pressure and fibronectin 1 upregulate TGFBR1, SMAD2, SMAD4, and ROCK1 genes and p-SMAD2 expression, activating multiple pathways.