Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: a randomized con
4 hours ago
- #oxidative stress
- #melatonin supplementation
- #multiple sclerosis
- A 12-week self-paced training regimen combined with melatonin supplementation enhanced antioxidant defenses in multiple sclerosis patients, increasing levels of reduced glutathione, total bilirubin, and uric acid.
- The combination of training and melatonin significantly reduced oxidative stress markers such as malondialdehyde and advanced oxidation protein products, along with lowering low-density lipoprotein cholesterol.
- Inflammatory markers, including white blood cells, neutrophils, and lymphocytes, decreased more in the combined intervention group compared to training or melatonin alone.
- Improvements in body composition were observed, with increased lean mass and reduced fat mass and body mass index in the group receiving both training and melatonin.
- The study concluded that the combined approach of training and melatonin is more effective than either intervention alone in reducing oxidative stress, inflammation, hyperlipidemia, and improving body composition in multiple sclerosis patients.