Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration - PubMed
5 hours ago
- #chronic viral infection
- #T cell exhaustion
- #KLF2
- KLF2 promotes expression of migratory genes in CD8+ T cells, while KLF3 encourages tissue residency by limiting migration-related programs.
- CD8+ T cell location influences their fate: moving cells out of tissue shifts differentiation from terminally exhausted (Texh) to effector-like exhausted (Teff) cells.
- KLF2 and KLF3 form a reciprocal regulatory circuit where KLF2 induces KLF3, and KLF3 in turn suppresses Klf2 transcription, competing for shared chromatin-binding sites to control exhaustion in chronic viral infection.