TIMP3 Suppresses Oxidative Stress and Ferroptosis of Lens Epithelial Cells in Cataract Through Regulating the Keap1/Nrf2 Pathway - PubMed
2 months ago
- #TIMP3
- #cataract
- #ferroptosis
- TIMP3 suppresses oxidative stress and ferroptosis in lens epithelial cells in cataract.
- Oxidative stress-induced lens epithelial cell death is key in cataract development.
- Ferroptosis, caused by lipid peroxide accumulation and ROS overproduction, is significant in cataract.
- TIMP3 overexpression reduces lipid peroxidation and ROS accumulation in lens epithelial cells.
- TIMP3 overexpression inactivates Keap1 and enhances Nrf2, HO-1, and GPX4 expression.
- TIMP3 overexpression delays cataract formation in rat models.
- TIMP3 knockdown has opposite effects, increasing oxidative stress and ferroptosis.
- The study suggests TIMP3 as a potential antioxidative treatment for cataract.