Myeloid-Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis - PubMed
8 hours ago
- #inflammation
- #periodontitis
- #bone remodeling
- Grancalcin (GCA), a protein from myeloid cells, is found in higher levels in gingival tissues during periodontitis.
- Removing GCA genetically reduces periodontal inflammation and pathological bone loss in mice.
- GCA interacts with CD44 on gingival fibroblasts, activating MYH9 and the NF-κB pathway to increase inflammation.
- A GCA-neutralizing antibody delivered via a thermosensitive hydrogel alleviates periodontitis, suggesting therapeutic potential.
- GCA is identified as a new regulator, marker, and target for periodontitis treatment.