Endoplasmic reticulum stress in Parkinson's disease: A pivotal role in cell fate and a therapeutic target - PubMed
4 days ago
- #Parkinson's disease
- #Endoplasmic reticulum stress
- #Cell fate
- The endoplasmic reticulum (ER) is crucial for protein synthesis, lipid metabolism, Ca²⁺ storage, and cellular homeostasis.
- ER stress plays a key role in determining cell fate, including apoptosis, autophagic cell death, necroptosis, pyroptosis, calcium-induced cell death, and ferroptosis.
- ER stress is involved in dopaminergic neuron degeneration in Parkinson's disease (PD), triggered by chemical inducers, α-synuclein accumulation, and genetic mutations.
- Small-molecule compounds targeting ER stress can regulate PD development, offering potential therapeutic approaches.
- Specific regulation of ER stress may provide neuroprotective benefits for PD.