Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis - PubMed
6 hours ago
- #hydrocephalus
- #ciliogenesis
- #Piezo1
- Piezo1 ion channel is highly expressed in mature choroid plexus epithelial cells (CPECs), mediating mechanotransduction in response to CSF flow and cell-cell contacts.
- Piezo1 knockout or overexpression in CPECs causes severe hydrocephalus in mice, reducing CSF flow, disrupting ciliary maintenance, and altering cilia-related gene expression.
- Piezo1 maintains calcium homeostasis in CPECs, regulating ciliogenesis and linking mechanical signals to cerebrospinal fluid production and hydrocephalus pathology.