Addressing Key Limitations of Diastolic Function Assessment in Mouse Echocardiography by Enabling Robust Retrospective Analysis From a Standard Imaging View - PubMed
3 days ago
- #retrospective analysis
- #mouse echocardiography
- #diastolic function
- E/A ratio and IVRT assessment in mice is challenging due to wave fusion at high heart rates, especially around 460 bpm in normal and HFpEF mice, while HFrEF shows fusion independent of heart rate.
- A non-A4C-view-dependent echocardiographic measurement (NAEM) approach using PSLAX B-mode cine loops enabled IVRT measurement with strong agreement to Doppler reference (r2=0.9339) and minimal bias, but E/A ratio performance was inadequate.
- NAEM supports murine diastolic function assessment algorithms without dedicated Doppler, lowering technical barriers and enabling retrospective analysis of existing datasets using standard imaging views.