The Protective Effects of Dendrobine on LPS-Induced Neuroinflammation and Related Mechanisms Based on Microglial M1/M2 Polarization - PubMed
5 hours ago
- #microglial polarization
- #neuroinflammation
- #dendrobine
- Dendrobine (DDB), an active ingredient in Dendrobium, exhibits neuroprotective properties.
- The study explores DDB's effects on LPS-induced neuroinflammation in BV2 microglial cells.
- DDB significantly reduces NO release and ROS levels in LPS-induced BV2 cells.
- DDB decreases pro-inflammatory mediators (TNF-α, IL-6, IL-1β) and increases anti-inflammatory mediators (IL-10, Arg-1).
- DDB shifts microglial polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotype.
- Findings suggest DDB as a potential compound for preventing neuroinflammation-related disorders.