Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis - PubMed
5 hours ago
- #Rheumatoid Arthritis
- #Drug Delivery
- #Nanoparticles
- Microneedle patches deliver GLP-1RAs-loaded nanoparticles for rheumatoid arthritis treatment.
- GLP-1RAs inhibit chondrocyte ferroptosis via the cGAS-STING pathway and promote macrophage M2 polarization.
- Cartilage-targeting silk fibroin nanoparticles modified with WYRGRL peptide enhance localized drug delivery.
- Composite microneedle system enables painless transdermal delivery and accumulates in arthritic joints.
- Study identifies cGAS-STING-ferroptosis as a druggable target and offers a new delivery platform for RA.