KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3 - PubMed
5 hours ago
- #tissue-resident
- #KLF2
- #memory CD8 T cells
- KLF2 overrides resident memory CD8 T cell differentiation, opposing KLF3.
- KLF2 ablation leads to rapid transcriptional reprogramming, preventing recirculation and promoting resident memory cell (TRM) traits.
- KLF2-deficient memory CD8+ T cells retain recall response capability, including pathogen control.
- KLF3 ablation enhances recirculating T cell subsets and limits TRM production in lymphoid tissues.
- Both KLF2 and KLF3 are essential for long-lived effector cell differentiation, indicating cooperative roles.
- KLFs play a central role in coordinating CD8+ T cell differentiation and trafficking.