Proton-activated chloride channel PACC1 as acid sensor in epidermal desquamation - PubMed
6 hours ago
- #epidermal desquamation
- #PACC1
- #acid sensation
- PACC1 is identified as the primary proton sensor in the skin's acidic stratum corneum, essential for triggering epidermal desquamation.
- Activation of PACC1 by protons leads to chloride efflux and activates the JNK/AP-1 signaling pathway, increasing kallikreins (KLK5/7) expression and secretion.
- Loss of PACC1 function through knockdown, knockout, or mutation prevents acid-induced KLK upregulation and desquamation, which can be restored with functional PACC1.
- The findings suggest PACC1's role as a core sensor converting acidification into desquamation signals, offering insights for therapeutic and cosmetic skin barrier strategies.