Ipriflavone From Aquilaria malaccensis Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviatin
5 hours ago
- #gastrointestinal mucosal injury
- #hypoxia-inducible factor
- #ferroptosis
- Hypoxia-induced gastrointestinal mucosal injury is linked to ferroptosis mediated by HIF-α.
- AELNs from Aquilaria malaccensis Lam. reduce HIF-1α expression and alleviate mucosal ferroptosis in hypoxia.
- Ipriflavone, a key metabolite in AELNs, inhibits HIF-α by targeting PHD2 to enhance hydroxylation.
- This inhibition downregulates PUFA-phospholipids, NOX4, and ALOX5, reducing ferroptosis.
- Ipriflavone shows promise as a HIF-α inhibitor for treating hypoxia-related gastrointestinal disorders.