Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression - PubMed
6 hours ago
- #transcriptional repression
- #RNase L
- #antiviral response
- RNase L is an antiviral factor that degrades both viral and cellular RNA in the cytoplasm.
- Cytoplasmic RNase L activity leads to transcriptional repression in the nucleus, affecting RNA polymerase II elongation.
- Immune-related genes are notably downregulated, suggesting RNase L's role in modulating immune responses.
- RNase L activation disrupts nucleoli and reduces transcription by RNA polymerases I and III.
- The study highlights crosstalk between RNA decay and transcription in gene expression modulation.