ZDHHC9-mediated KLF5 palmitoylation enhances the cAMP/PKA/CREB axis to promote colorectal cancer progression - PubMed
5 hours ago
- #cAMP signaling
- #colorectal cancer
- #palmitoylation
- ZDHHC9 is upregulated in colorectal cancer (CRC) and linked to poor prognosis.
- ZDHHC9 knockdown inhibits CRC cell proliferation and migration in vitro and in vivo.
- ZDHHC9 promotes S-palmitoylation of KLF5 at cysteine 438, enhancing ADCY4 activity.
- Increased ADCY4 activity raises intracellular cAMP levels, activating the cAMP/PKA/CREB pathway.
- Activation of this pathway drives CRC progression, including proliferation, migration, and 5-FU resistance.
- Targeting the ZDHHC9/KLF5/ADCY4 axis offers a novel therapeutic strategy for CRC.