BMI-mediated association between pulmonary function and bone mineral density moderated by age: Integrated Mendelian randomisation and cross-sectional study - PubMed
4 hours ago
- #BMI mediation
- #bone mineral density
- #pulmonary function
- A cross-sectional study of 10,944 NHANES participants showed a dose-response relationship between lower FEV1/FVC (impaired pulmonary function) and reduced bone mineral density (BMD), with nonlinear associations.
- BMI partially mediated (11.7%) the association between pulmonary function and BMD, and this mediating effect varied significantly with age.
- Mendelian randomization analysis using GWAS data supported a causal link between genetically predicted impaired pulmonary function and increased osteoporosis risk.
- The findings suggest that interventions targeting BMI and considering age may help mitigate osteoporosis risk in individuals with airflow limitations.