Fisetin targets multiple signaling pathways to suppress microglia-mediated neuroinflammation and cognitive decline in Alzheimer's disease - PubMed
5 hours ago
- #Alzheimer's disease
- #Neuroinflammation
- #Fisetin
- Fisetin improves cognitive performance in APP/PS1 mice and reduces amyloid pathology.
- Fisetin inhibits pro-inflammatory activation in microglia and reduces mitochondrial ROS overproduction.
- PI3K identified as a key signaling node in fisetin's regulation of microglial inflammatory responses.
- Fisetin modulates the PI3K-Akt-NF-κB axis to limit NF-κB nuclear translocation and cytokine release.
- Conditioned medium from fisetin-treated microglia alleviates neuronal damage and restores BDNF and PSD95 expression.
- PI3K may act as a molecular target of fisetin, highlighting its therapeutic potential in Alzheimer's disease.