A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin-3-Gallate Supplementation on Serum Brain-Derived Neurotrophic Factor and Mood Disturbance in Adults - PubMed
4 hours ago
- #BDNF
- #supplementation
- #mood disorders
- A randomized controlled trial investigated the effects of combined curcumin and EGCG supplementation on mood disturbance and serum BDNF levels in adults.
- Participants (n=64) were divided into supplement (350 mg EGCG + 1330 mg curcumin daily) or placebo groups for 8 weeks.
- Mood, sleep, and physical activity improved significantly in both groups, with no significant difference between supplement and placebo.
- Serum BDNF levels increased in both groups, but changes were not statistically significant.
- Sugar intake was positively correlated with mood symptoms in the supplement group at Week 8.
- Baseline fruit and vegetable intake was linked to mood symptom severity at certain time points.
- The study concluded that EGCG and curcumin supplementation did not provide additional benefits over placebo for mood or BDNF levels.
- Behavioral or lifestyle factors may have a greater impact on short-term mood improvements than supplementation alone.