Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration - PubMed
4 hours ago
- #Efferocytosis
- #Macrophage Angiogenesis
- #Bone Marrow Regeneration
- Efferocytosis (the clearance of dying cells) enhances macrophage pro-angiogenic functions, promoting bone marrow vascular regeneration after transplantation.
- Dying cell-derived products, including sphingosine-1-phosphate (S1P), prime hypoxia-inducible factor-1α (HIF-1α) gene expression in macrophages.
- Degradation of apoptotic bodies elevates intracellular cholesterol, activating liver X receptor α (LXRα), which binds to HIF-1α to inhibit its ubiquitylation and boost VEGFA expression.
- The LXRα/HIF-1α axis is essential for macrophage-driven vascular repair post-transplantation, as shown in transgenic mouse models and liposome-mediated delivery studies.
- This reveals a novel beneficial role of efferocytosis in macrophage pro-healing functions during injury, offering therapeutic potential for improving hematopoietic regeneration.