De novo identification of the specificities of recurrently identified human T cell receptors - PubMed
8 days ago
- #Viral infections
- #Immunology
- #T cell receptors
- Public T cell receptors (TCRs) are shared among individuals and target immunodominant epitopes.
- A functional screening workflow was developed to identify antigen specificities of public TCRs.
- The workflow involves screening TCRs against viral genomes or reference strains and sorting immunogenic peptides.
- Identified TCRs target seasonal coronaviruses, influenza B, and Herpesviridae family viruses.
- Some TCRs show cross-reactivity with peptides from pandemic coronaviruses.
- The study provides insights into shared immune exposures and population-level immune histories.