ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney Disease - PubMed
5 hours ago
- #Kidney Fibrosis
- #ACLY
- #Histone Acetylation
- ACLY-driven metabolic reprogramming increases histone H3 lysine 27 acetylation (H3K27ac) in chronic kidney disease models.
- Tubule-specific deletion of Acly reduces acetyl-CoA, H3K27ac, and attenuates kidney fibrosis in mice.
- Loss of Acly decreases chromatin accessibility at pro-inflammatory genes like Jak1 and Jak2, reducing their expression.
- Higher ACLY expression correlates with worse kidney function and increased JAK1/2 expression in human CKD samples.
- ACLY inhibitors, such as bempedoic acid, replicate antifibrotic effects in mice, suggesting therapeutic potential for CKD.