Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer's disease: a study combining network pharmacology, transcriptomics,
4 days ago
- #Alzheimer's disease
- #Ferroptosis
- #Traditional Chinese Medicine
- The study explores how Yangming-Kaixin-Yizhi formula (YKY) inhibits neuronal ferroptosis via Nrf2 in Alzheimer's disease (AD).
- YKY, a traditional Chinese medicine, improved learning, memory, and reduced neuronal loss in 3×Tg-AD mice.
- Transcriptomics and network pharmacology suggested YKY's mechanism involves iron metabolism, ferroptosis, and Nrf2-regulated gene transcription.
- YKY reduced iron deposition, ROS, and lipid peroxidation, while promoting Nrf2 and related proteins (SLC7A11, GPX4, FTH1).
- The findings provide scientific evidence for YKY's use in treating memory-related disorders like AD.