O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy - PubMed
5 hours ago
- #Autophagy
- #Ischemia-Reperfusion Injury
- #YAP1
- O-GlcNAcylation of YAP1 exacerbates lung transplant ischemia-reperfusion injury.
- Hypoxia-reoxygenation activates the Hippo-YAP1 pathway, increasing lung epithelial cell damage.
- Autophagy and mitophagy levels rise significantly during ischemia-reperfusion, indicating cellular stress.
- YAP1 knockdown reduces autophagy and mitophagy under hypoxia-reoxygenation and ischemia-reperfusion conditions.
- OGT-mediated O-GlcNAc modification of YAP1 enhances its interaction with HIF1α, activating hypoxia-responsive molecules.
- Knockdown of OGT mitigates autophagy, mitophagy, and associated damage in lung epithelial cells and transplant tissues.
- The study suggests potential therapeutic targets for reducing lung transplant ischemia-reperfusion injury.