Targeting the macrophage mechanosensing regulator CKAP4 accelerates the inflammatory-to-proliferative transition in wound healing - PubMed
2 hours ago
- #macrophage mechanosensing
- #wound healing
- #CKAP4
- Loss of CKAP4 in macrophages accelerates wound closure and inflammation resolution in mice.
- CKAP4 binds to Talin1 to restrain adhesion signaling and STAT6 nuclear translocation.
- CKAP4 deficiency increases macrophage sensitivity to matrix stiffness, promoting cytoskeletal remodeling and pro-regenerative programs at lower stiffness thresholds.
- In diabetic wound models, local silencing of CKAP4 restores macrophage mechanoresponsiveness and improves healing.
- CKAP4 acts as a negative regulator of macrophage mechanosensing, and targeting it offers a potential mechanotherapeutic approach for wound treatment.