Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition - PubMed
5 hours ago
- #immunotherapy
- #colorectal-cancer
- #multi-omics
- A novel immune classification for colorectal cancer (CRC) was developed using multi-omics analysis.
- Three distinct clusters were identified: Cluster1 (high WNT pathway activation, poor prognosis), Cluster2 (low immune infiltration, high glycolysis), and Cluster3 (high gene methylation, better immunotherapy response).
- Cluster1 may benefit from combined immunotherapy and WNT-targeted treatment.
- Cluster2 patients could respond well to metabolism inhibitors.
- Cluster3 shows high tumor mutation burden and better immunotherapy efficacy.
- The classification system, MotifCC, helps tailor immunotherapy strategies for CRC patients.