Extracellular Vesicles Reflect Thrombo-Inflammatory, Endothelial and Tissue-Remodelling Changes in Cirrhosis - PubMed

5 hours ago

Extracellular vesicles (EVs) were studied in cirrhosis patients, showing increases in total, platelet-derived, endothelial, immune-derived, and tissue remodelling-associated EVs across Child-Pugh stages.
EVs reflect progressive thrombo-inflammatory, endothelial, and tissue-remodelling changes in cirrhosis, but were not independently associated with clinical outcomes like decompensation or mortality.
In compensated cirrhosis, first hepatic decompensation was linked to higher MELD and Child-Pugh scores, alcohol-related aetiology, and lower platelet count, but not EVs after adjustment.
In decompensated cirrhosis, higher CRP levels were associated with further decompensation, ACLF, or liver-related death, while EVs did not show independent associations.

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