XIAOSHUI formula inhibits malignant pleural effusion by targeting the STC1/p65/CXCL5 axis to reprogram tumor-associated macrophages - PubMed
6 hours ago
- #Malignant pleural effusion
- #Xiaoshui formula
- #Tumor microenvironment
- XIAOSHUI formula (XSF) inhibits malignant pleural effusion (MPE) by targeting the STC1/p65/CXCL5 axis.
- MPE is a common complication in advanced lung carcinoma, driven by an immunosuppressive tumor microenvironment (TME).
- XSF modulates tumor-associated macrophages (TAMs) polarization, enhancing anti-tumor T cell function.
- XSF treatment reduces pleural effusion volume and suppresses tumor-derived CXCL5, impairing M2 polarization of TAMs.
- The study provides a mechanistic foundation for the clinical application of XSF in MPE treatment.