Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice - PubMed
a day ago
- #Phosphorylation
- #Runx protein
- #T cell differentiation
- Phosphorylation of the Runx protein's terminal Y residue in the WRPY motif is crucial for CD8+ T cell lineage choice.
- This phosphorylation enhances interaction with TLE co-repressors, leading to Cd4-Thpok silencing in cytotoxic lineage T cells.
- Non-receptor tyrosine kinases Lck and Zap70 interact more with Runx in MHC-I-signaled CD4-CD8+ thymocytes.
- The study links MHC restriction to helper vs. cytotoxic T cell lineage choice through differential Runx phosphorylation states.