Host-directed Therapy for Tuberculosis: Repurposed Drugs towards Global Tuberculosis Elimination - PubMed
5 hours ago
- #Tuberculosis
- #Drug repurposing
- #Host-directed therapy
- Tuberculosis (TB) remains the leading infectious cause of death globally despite WHO's End TB Strategy.
- Host-directed therapies (HDTs) are emerging as a promising adjunctive strategy to enhance bacterial clearance and reduce immunopathology.
- HDTs target various host pathways including autophagy, inflammatory signaling, immunomodulation, and lipid metabolism.
- Repurposed drugs like metformin, vitamin D, NSAIDs, and statins are being explored for HDT in TB.
- HDTs show potential benefits in pulmonary and extrapulmonary TB, as well as TB-associated comorbidities like HIV and diabetes.
- Large-scale Phase III trials are needed to integrate HDTs into standard clinical practice for TB treatment.