CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts - PubMed
5 hours ago
- #immunosuppression
- #tuberculosis
- #CD8+ T cells
- CD8+ T cells play a crucial role in sustaining vaccination-induced immunity against tuberculosis (TB) dissemination in immunosuppressed hosts.
- Immunosuppression, such as HIV coinfection, increases the risk of latent TB infection (LTBI) reactivation, but the immunological mechanisms maintaining LTBI are not well understood.
- Vaccination with BCG or recombinant BCG can prevent lymphatic Mtb dissemination and progressive disease even in the absence of CD4+ T cells.
- Multi-parameter imaging and spatial transcriptomics reveal distinct immune cell repositioning at TB lesion edges in lymph nodes during CD4+ T cell loss.
- B cells are not essential for Mtb containment during CD4+ T cell depletion; instead, CD8+ T cells mediate vaccination-induced prevention of Mtb dissemination.
- The findings inform LTBI management strategies for immunocompromised individuals.